Research ArticleShort Communication
The 2-Hydroxyiminostilbene Metabolite of Carbamazepine or the Supernatant from Incubation of Hepatocytes with Carbamazepine Activates Inflammasomes: Implications for Carbamazepine-Induced Hypersensitivity Reactions
Ryuji Kato, Yoshio Ijiri, Tetsuya Hayashi and Jack Uetrecht
Drug Metabolism and Disposition October 2019, 47 (10) 1093-1096; DOI: https://doi.org/10.1124/dmd.119.087981
Ryuji Kato
Department of Cardiovascular Pharmacotherapy and Toxicology, Osaka University of Pharmaceutical Sciences, Osaka, Japan (R.K., Y.I., T.H.) and Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada (J.U.)
Yoshio Ijiri
Department of Cardiovascular Pharmacotherapy and Toxicology, Osaka University of Pharmaceutical Sciences, Osaka, Japan (R.K., Y.I., T.H.) and Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada (J.U.)
Tetsuya Hayashi
Department of Cardiovascular Pharmacotherapy and Toxicology, Osaka University of Pharmaceutical Sciences, Osaka, Japan (R.K., Y.I., T.H.) and Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada (J.U.)
Jack Uetrecht
Department of Cardiovascular Pharmacotherapy and Toxicology, Osaka University of Pharmaceutical Sciences, Osaka, Japan (R.K., Y.I., T.H.) and Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada (J.U.)
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Research ArticleShort Communication
Carbamazepine Metabolite and Hypersensitivity Reactions
Ryuji Kato, Yoshio Ijiri, Tetsuya Hayashi and Jack Uetrecht
Drug Metabolism and Disposition October 1, 2019, 47 (10) 1093-1096; DOI: https://doi.org/10.1124/dmd.119.087981
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