Research ArticleArticle
The Hypoglycemic Effect of Berberine and Berberrubine Involves Modulation of Intestinal Farnesoid X Receptor Signaling Pathway and Inhibition of Hepatic Gluconeogenesis
Runbin Sun, Bo Kong, Na Yang, Bei Cao, Dong Feng, Xiaoyi Yu, Chun Ge, Siqi Feng, Fei Fei, Jingqiu Huang, Zhenyao Lu, Yuan Xie, Chung S. Yang, Grace L. Guo, Guangji Wang and Jiye Aa
Drug Metabolism and Disposition March 2021, 49 (3) 276-286; DOI: https://doi.org/10.1124/dmd.120.000215
Runbin Sun
Jiangsu Province Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China (R.S., D.F., X.Y., C.G., S.F., J.H., Z.L., Y.X., G.W., J.A.); Department of Pharmacology and Toxicology (B.K., G.L.G.) and Department of Chemical Biology (C.S.Y.), Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey; and Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, China (N.Y., B.C., F.F.)
Bo Kong
Jiangsu Province Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China (R.S., D.F., X.Y., C.G., S.F., J.H., Z.L., Y.X., G.W., J.A.); Department of Pharmacology and Toxicology (B.K., G.L.G.) and Department of Chemical Biology (C.S.Y.), Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey; and Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, China (N.Y., B.C., F.F.)
Na Yang
Jiangsu Province Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China (R.S., D.F., X.Y., C.G., S.F., J.H., Z.L., Y.X., G.W., J.A.); Department of Pharmacology and Toxicology (B.K., G.L.G.) and Department of Chemical Biology (C.S.Y.), Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey; and Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, China (N.Y., B.C., F.F.)
Bei Cao
Jiangsu Province Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China (R.S., D.F., X.Y., C.G., S.F., J.H., Z.L., Y.X., G.W., J.A.); Department of Pharmacology and Toxicology (B.K., G.L.G.) and Department of Chemical Biology (C.S.Y.), Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey; and Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, China (N.Y., B.C., F.F.)
Dong Feng
Jiangsu Province Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China (R.S., D.F., X.Y., C.G., S.F., J.H., Z.L., Y.X., G.W., J.A.); Department of Pharmacology and Toxicology (B.K., G.L.G.) and Department of Chemical Biology (C.S.Y.), Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey; and Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, China (N.Y., B.C., F.F.)
Xiaoyi Yu
Jiangsu Province Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China (R.S., D.F., X.Y., C.G., S.F., J.H., Z.L., Y.X., G.W., J.A.); Department of Pharmacology and Toxicology (B.K., G.L.G.) and Department of Chemical Biology (C.S.Y.), Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey; and Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, China (N.Y., B.C., F.F.)
Chun Ge
Jiangsu Province Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China (R.S., D.F., X.Y., C.G., S.F., J.H., Z.L., Y.X., G.W., J.A.); Department of Pharmacology and Toxicology (B.K., G.L.G.) and Department of Chemical Biology (C.S.Y.), Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey; and Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, China (N.Y., B.C., F.F.)
Siqi Feng
Jiangsu Province Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China (R.S., D.F., X.Y., C.G., S.F., J.H., Z.L., Y.X., G.W., J.A.); Department of Pharmacology and Toxicology (B.K., G.L.G.) and Department of Chemical Biology (C.S.Y.), Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey; and Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, China (N.Y., B.C., F.F.)
Fei Fei
Jiangsu Province Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China (R.S., D.F., X.Y., C.G., S.F., J.H., Z.L., Y.X., G.W., J.A.); Department of Pharmacology and Toxicology (B.K., G.L.G.) and Department of Chemical Biology (C.S.Y.), Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey; and Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, China (N.Y., B.C., F.F.)
Jingqiu Huang
Jiangsu Province Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China (R.S., D.F., X.Y., C.G., S.F., J.H., Z.L., Y.X., G.W., J.A.); Department of Pharmacology and Toxicology (B.K., G.L.G.) and Department of Chemical Biology (C.S.Y.), Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey; and Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, China (N.Y., B.C., F.F.)
Zhenyao Lu
Jiangsu Province Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China (R.S., D.F., X.Y., C.G., S.F., J.H., Z.L., Y.X., G.W., J.A.); Department of Pharmacology and Toxicology (B.K., G.L.G.) and Department of Chemical Biology (C.S.Y.), Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey; and Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, China (N.Y., B.C., F.F.)
Yuan Xie
Jiangsu Province Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China (R.S., D.F., X.Y., C.G., S.F., J.H., Z.L., Y.X., G.W., J.A.); Department of Pharmacology and Toxicology (B.K., G.L.G.) and Department of Chemical Biology (C.S.Y.), Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey; and Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, China (N.Y., B.C., F.F.)
Chung S. Yang
Jiangsu Province Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China (R.S., D.F., X.Y., C.G., S.F., J.H., Z.L., Y.X., G.W., J.A.); Department of Pharmacology and Toxicology (B.K., G.L.G.) and Department of Chemical Biology (C.S.Y.), Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey; and Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, China (N.Y., B.C., F.F.)
Grace L. Guo
Jiangsu Province Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China (R.S., D.F., X.Y., C.G., S.F., J.H., Z.L., Y.X., G.W., J.A.); Department of Pharmacology and Toxicology (B.K., G.L.G.) and Department of Chemical Biology (C.S.Y.), Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey; and Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, China (N.Y., B.C., F.F.)
Guangji Wang
Jiangsu Province Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China (R.S., D.F., X.Y., C.G., S.F., J.H., Z.L., Y.X., G.W., J.A.); Department of Pharmacology and Toxicology (B.K., G.L.G.) and Department of Chemical Biology (C.S.Y.), Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey; and Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, China (N.Y., B.C., F.F.)
Jiye Aa
Jiangsu Province Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China (R.S., D.F., X.Y., C.G., S.F., J.H., Z.L., Y.X., G.W., J.A.); Department of Pharmacology and Toxicology (B.K., G.L.G.) and Department of Chemical Biology (C.S.Y.), Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey; and Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, China (N.Y., B.C., F.F.)
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Research ArticleArticle
BBR and berberrubine Inhibited Gluconeogenesis through FXR
Runbin Sun, Bo Kong, Na Yang, Bei Cao, Dong Feng, Xiaoyi Yu, Chun Ge, Siqi Feng, Fei Fei, Jingqiu Huang, Zhenyao Lu, Yuan Xie, Chung S. Yang, Grace L. Guo, Guangji Wang and Jiye Aa
Drug Metabolism and Disposition March 1, 2021, 49 (3) 276-286; DOI: https://doi.org/10.1124/dmd.120.000215
Research ArticleArticle
BBR and berberrubine Inhibited Gluconeogenesis through FXR
Runbin Sun, Bo Kong, Na Yang, Bei Cao, Dong Feng, Xiaoyi Yu, Chun Ge, Siqi Feng, Fei Fei, Jingqiu Huang, Zhenyao Lu, Yuan Xie, Chung S. Yang, Grace L. Guo, Guangji Wang and Jiye Aa
Drug Metabolism and Disposition March 1, 2021, 49 (3) 276-286; DOI: https://doi.org/10.1124/dmd.120.000215
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