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Research ArticleArticle

Application of Quantitative NMR in Pharmacological Evaluation of Biologically Generated Metabolites: Implications in Drug Discovery

Abdul Mutlib, Robert Espina, Karthick Vishwanathan, Kathlene Babalola, Zecheng Chen, Christoph Dehnhardt, Aranapakam Venkatesan, Tarek Mansour, Inder Chaudhary, Rasmy Talaat and JoAnn Scatina
Drug Metabolism and Disposition January 2011, 39 (1) 106-116; DOI: https://doi.org/10.1124/dmd.110.032490

Article Information

vol. 39 no. 1 106-116
DOI 
https://doi.org/10.1124/dmd.110.032490
PubMed 
20952552
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received February 1, 2010
  • Accepted October 15, 2010
  • Published online December 15, 2010.

Article Versions

Copyright & Usage 
Copyright © 2011 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Abdul Mutlib,
  2. Robert Espina,
  3. Karthick Vishwanathan,
  4. Kathlene Babalola,
  5. Zecheng Chen,
  6. Christoph Dehnhardt,
  7. Aranapakam Venkatesan,
  8. Tarek Mansour,
  9. Inder Chaudhary,
  10. Rasmy Talaat, and
  11. JoAnn Scatina
  1. Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Collegeville, Pennsylvania (A.M., R.E., K.V., K.B., I.C., R.T., J.S.); and Department of Chemical Sciences, Pfizer Global Research and Development, Pearl River, New York (Z.C., C.D., A.V., T.M.)
  1. Address correspondence to:
    Dr. A. E. Mutlib, Drug Metabolism and Pharmacokinetics, Frontage Laboratories, 105 Great Valley Pkwy., Malvern, PA 19355. E-mail: amutlib{at}frontagelab.com Partial 1H NMR spectra of the aliphatic region of M1 (bottom) and synthetic standards of the endo-isomer M1a (middle), and exo-isomer M1b (top). High-resolution MS/MS spectra of M1
    and the endo-isomer (M1a
    ) and exo-isomer (M1b
    ).
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Application of Quantitative NMR in Pharmacological Evaluation of Biologically Generated Metabolites: Implications in Drug Discovery

Abdul Mutlib, Robert Espina, Karthick Vishwanathan, Kathlene Babalola, Zecheng Chen, Christoph Dehnhardt, Aranapakam Venkatesan, Tarek Mansour, Inder Chaudhary, Rasmy Talaat and JoAnn Scatina
Drug Metabolism and Disposition January 1, 2011, 39 (1) 106-116; DOI: https://doi.org/10.1124/dmd.110.032490
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