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Comparison of 19F NMR and 14C Measurements for the Assessment of ADME of BYL719 (Alpelisib) in Humans

Alexander David James, Cyrille Marvalin, Alexandre Luneau, Axel Meissner and Gian Camenisch
Drug Metabolism and Disposition August 2017, 45 (8) 900-907; DOI: https://doi.org/10.1124/dmd.117.075424

Article Information

vol. 45 no. 8 900-907
DOI 
https://doi.org/10.1124/dmd.117.075424
PubMed 
28566285
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received February 13, 2017
  • Accepted May 22, 2017
  • Published online July 10, 2017.

Article Versions

Copyright & Usage 
Copyright © 2017 by The Author(s) This is an open access article distributed under the CC BY-NC Attribution 4.0 International license.

Author Information

  1. Alexander David James,
  2. Cyrille Marvalin,
  3. Alexandre Luneau,
  4. Axel Meissner, and
  5. Gian Camenisch
  1. PK Sciences (ADME), Novartis Institutes for Biomedical Research, Basel, Switzerland (A.D.J., C.M., G.C.); and AX, Global Discovery Chemistry, Novartis Institutes for Biomedical Research Basel, Switzerland (A.L., A.M.)
  1. Address correspondence to:
    Alexander David James, Novartis Institutes for Biomedical Research, PK Sciences (ADME), Fabrikstrasse 14, CH-4002 Basel, Switzerland. E-mail: alexander_david.james{at}novartis.com
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Research ArticleArticle

Use of 19F NMR To Assess ADME of Alpelisib

Alexander David James, Cyrille Marvalin, Alexandre Luneau, Axel Meissner and Gian Camenisch
Drug Metabolism and Disposition August 1, 2017, 45 (8) 900-907; DOI: https://doi.org/10.1124/dmd.117.075424
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