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Research ArticleArticle

Mathematical and Experimental Validation of Flux Dialysis Method: An Improved Approach to Measure Unbound Fraction for Compounds with High Protein Binding and Other Challenging Properties

J. Cory Kalvass, Colin Phipps, Gary J. Jenkins, Patricia Stuart, Xiaomei Zhang, Lance Heinle, Marjoleen J. M. A. Nijsen and Volker Fischer
Drug Metabolism and Disposition April 2018, 46 (4) 458-469; DOI: https://doi.org/10.1124/dmd.117.078915

Article Information

vol. 46 no. 4 458-469
DOI 
https://doi.org/10.1124/dmd.117.078915
PubMed 
29437872
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received October 19, 2017
  • Accepted January 31, 2018
  • Published online March 2, 2018.

Article Versions

Copyright & Usage 
Copyright © 2018 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. J. Cory Kalvass,
  2. Colin Phipps,
  3. Gary J. Jenkins,
  4. Patricia Stuart,
  5. Xiaomei Zhang,
  6. Lance Heinle,
  7. Marjoleen J. M. A. Nijsen, and
  8. Volker Fischer
  1. Drug Metabolism, Pharmacokinetics and Bioanalysis, Research and Development, AbbVie, North Chicago, Illinois
  1. Address correspondence to:
    J. Cory Kalvass, Drug Metabolism, Pharmacokinetics and Bioanalysis, Research and Development, AbbVie Inc, Dept. R46V, Bldg. AP9-1, 1 North Waukegan Road, North Chicago, IL 60064-6104. E-mail: j.kalvass{at}abbvie.com
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Research ArticleArticle

Determination of Unbound Fraction by Flux Dialysis Method

J. Cory Kalvass, Colin Phipps, Gary J. Jenkins, Patricia Stuart, Xiaomei Zhang, Lance Heinle, Marjoleen J. M. A. Nijsen and Volker Fischer
Drug Metabolism and Disposition April 1, 2018, 46 (4) 458-469; DOI: https://doi.org/10.1124/dmd.117.078915
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