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Mathematical and Experimental Validation of Flux Dialysis Method: An Improved Approach to Measure Unbound Fraction for Compounds with High Protein Binding and Other Challenging Properties

J. Cory Kalvass, Colin Phipps, Gary J. Jenkins, Patricia Stuart, Xiaomei Zhang, Lance Heinle, Marjoleen J. M. A. Nijsen and Volker Fischer
Drug Metabolism and Disposition April 2018, 46 (4) 458-469; DOI: https://doi.org/10.1124/dmd.117.078915
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Research ArticleArticle

Determination of Unbound Fraction by Flux Dialysis Method

J. Cory Kalvass, Colin Phipps, Gary J. Jenkins, Patricia Stuart, Xiaomei Zhang, Lance Heinle, Marjoleen J. M. A. Nijsen and Volker Fischer
Drug Metabolism and Disposition April 1, 2018, 46 (4) 458-469; DOI: https://doi.org/10.1124/dmd.117.078915
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