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Research ArticleSpecial Section on Transporters in Drug Disposition and Pharmacokinetic Prediction

Interindividual Differences in the Expression of ATP-Binding Cassette and Solute Carrier Family Transporters in Human Skin: DNA Methylation Regulates Transcriptional Activity of the Human ABCC3 Gene

Tomoki Takechi, Takeshi Hirota, Tatsuya Sakai, Natsumi Maeda, Daisuke Kobayashi and Ichiro Ieiri
Drug Metabolism and Disposition May 2018, 46 (5) 628-635; DOI: https://doi.org/10.1124/dmd.117.079061

Article Information

vol. 46 no. 5 628-635
DOI 
https://doi.org/10.1124/dmd.117.079061
PubMed 
29437875
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received October 19, 2017
  • Accepted January 30, 2018
  • Published online April 10, 2018.

Article Versions

Copyright & Usage 
Copyright © 2018 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Tomoki Takechi,
  2. Takeshi Hirota,
  3. Tatsuya Sakai,
  4. Natsumi Maeda,
  5. Daisuke Kobayashi, and
  6. Ichiro Ieiri
  1. Department of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan (T.T., T.H., T.S., N.M., I.I.); Drug Development Research Laboratories, Kyoto R&D Center, Maruho Co., Ltd., Kyoto, Japan (T.T.); and Department of Clinical Pharmacy and Pharmaceutical Care, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan (D.K.)
  1. Address correspondence to:
    Ichiro Ieiri, Department of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. E-mail: ieiri-ttr{at}umin.ac.jp
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Research ArticleSpecial Section on Transporters in Drug Disposition and Pharmacokinetic Prediction

DNA Methylation Regulates MRP3 Expression in Human Skin

Tomoki Takechi, Takeshi Hirota, Tatsuya Sakai, Natsumi Maeda, Daisuke Kobayashi and Ichiro Ieiri
Drug Metabolism and Disposition May 1, 2018, 46 (5) 628-635; DOI: https://doi.org/10.1124/dmd.117.079061
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