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Research ArticleSpecial Section on Transporters in Drug Disposition and Pharmacokinetic Prediction

Brain Distribution of a Novel MEK Inhibitor E6201: Implications in the Treatment of Melanoma Brain Metastases

Gautham Gampa, Minjee Kim, Nicholas Cook-Rostie, Janice K. Laramy, Jann N. Sarkaria, Linda Paradiso, Louis DePalatis and William F. Elmquist
Drug Metabolism and Disposition May 2018, 46 (5) 658-666; DOI: https://doi.org/10.1124/dmd.117.079194

Article Information

vol. 46 no. 5 658-666
DOI 
https://doi.org/10.1124/dmd.117.079194
PubMed 
29437873
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received October 26, 2017
  • Accepted January 30, 2018
  • Published online April 10, 2018.

Article Versions

Copyright & Usage 
Copyright © 2018 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Gautham Gampa,
  2. Minjee Kim,
  3. Nicholas Cook-Rostie,
  4. Janice K. Laramy,
  5. Jann N. Sarkaria,
  6. Linda Paradiso,
  7. Louis DePalatis, and
  8. William F. Elmquist
  1. Brain Barriers Research Center, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota (G.G., M.K., N.C.-R., J.K.L., W.F.E.); Radiation Oncology, Mayo Clinic, Rochester, Minnesota (J.N.S.); and Strategia Therapeutics Inc., Spring, Texas (L.P., L.D.)
  1. Address correspondence to:
    Dr. William F. Elmquist, Department of Pharmaceutics, University of Minnesota, 308 Harvard Street SE, Minneapolis, MN 55455. E-mail: elmqu011{at}umn.edu
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Research ArticleSpecial Section on Transporters in Drug Disposition and Pharmacokinetic Prediction

Pharmacokinetics, Brain Distribution, and Binding of E6201

Gautham Gampa, Minjee Kim, Nicholas Cook-Rostie, Janice K. Laramy, Jann N. Sarkaria, Linda Paradiso, Louis DePalatis and William F. Elmquist
Drug Metabolism and Disposition May 1, 2018, 46 (5) 658-666; DOI: https://doi.org/10.1124/dmd.117.079194
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