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Defining the Contribution of CYP1A1 and CYP1A2 to Drug Metabolism Using Humanized CYP1A1/1A2 and Cyp1a1/Cyp1a2 Knockout Mice

Y. Kapelyukh, C. J. Henderson, N. Scheer, A. Rode and C. R. Wolf
Drug Metabolism and Disposition August 2019, 47 (8) 907-918; DOI: https://doi.org/10.1124/dmd.119.087718

Article Information

vol. 47 no. 8 907-918
DOI 
https://doi.org/10.1124/dmd.119.087718
PubMed 
31147315
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received April 23, 2019
  • Accepted May 28, 2019
  • Published online July 19, 2019.

Article Versions

Copyright & Usage 
Copyright © 2019 The Author(s). This is an open access article distributed under the CC BY Attribution 4.0 International license.

Author Information

  1. Y. Kapelyukh,
  2. C. J. Henderson,
  3. N. Scheer1,
  4. A. Rode2, and
  5. C. R. Wolf
  1. Systems Medicine, School of Medicine, University of Dundee, Jacqui Wood Cancer Centre, Ninewells Hospital, Dundee, United Kingdom (Y.K., C.J.H., C.R.W.) and Taconic Biosciences Inc., Rensselaer, New York (N.S., A.R.)
  1. Address correspondence to:
    C. R. Wolf, School of Medicine, University of Dundee, Jacqui Wood Cancer Centre, Ninewells Hospital, Dundee, DD1 9SY, UK. E-mail: c.r.wolf{at}dundee.ac.uk
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hCYP1A1/1A2 Mice for Drug Interaction Studies

Y. Kapelyukh, C. J. Henderson, N. Scheer, A. Rode and C. R. Wolf
Drug Metabolism and Disposition August 1, 2019, 47 (8) 907-918; DOI: https://doi.org/10.1124/dmd.119.087718
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