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Metabolism and Disposition of [14C]Pevonedistat, a First-in-Class NEDD8-Activating Enzyme Inhibitor, after Intravenous Infusion to Patients with Advanced Solid Tumors

Jayaprakasam Bolleddula, Hao Chen, Lawrence Cohen, Xiaofei Zhou, Sandeepraj Pusalkar, Allison Berger, Farhad Sedarati, Karthik Venkatakrishnan and Swapan K. Chowdhury
Drug Metabolism and Disposition July 2022, 50 (7) 989-997; DOI: https://doi.org/10.1124/dmd.122.000842

Article Information

vol. 50 no. 7 989-997
DOI 
https://doi.org/10.1124/dmd.122.000842
PubMed 
35504658
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received January 27, 2022
  • Accepted March 29, 2022
  • Published online July 6, 2022.

Article Versions

Copyright & Usage 
Copyright © 2022 by The Author(s) This is an open access article distributed under the CC BY-NC Attribution 4.0 International license.

Author Information

  1. Jayaprakasam Bolleddula1,
  2. Hao Chen,
  3. Lawrence Cohen,
  4. Xiaofei Zhou,
  5. Sandeepraj Pusalkar2,
  6. Allison Berger,
  7. Farhad Sedarati,
  8. Karthik Venkatakrishnan1, and
  9. Swapan K. Chowdhury3
  1. Takeda Development Center Americas, Inc., Lexington, Massachusetts
  1. Address correspondence to:
    Dr. Swapan K. Chowdhury, Boston Pharmaceuticals, 55 Cambridge Parkway Suite 400, Cambridge, MA 02142. E-mail: swapan{at}bostonpharmaceuticals.com; or Dr. Jayaprakasam Bolleddula. E-mail: bolleddulajp{at}yahoo.com
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Metabolism of Pevonedistat in Patients with Cancer

Jayaprakasam Bolleddula, Hao Chen, Lawrence Cohen, Xiaofei Zhou, Sandeepraj Pusalkar, Allison Berger, Farhad Sedarati, Karthik Venkatakrishnan and Swapan K. Chowdhury
Drug Metabolism and Disposition July 1, 2022, 50 (7) 989-997; DOI: https://doi.org/10.1124/dmd.122.000842
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