Research ArticleArticle
Differential Selectivity of Human and Mouse ABCC4/Abcc4 for Arsenic Metabolites
Brayden D. Whitlock, Yingze Ma, Gwenaëlle Conseil, Alicia R. O’Brien, Mayukh Banerjee, Diane P. Swanlund, Z. Ping Lin, Yao Wang, X. Chris Le, John D. Schuetz, Susan P.C. Cole and Elaine M. Leslie
Drug Metabolism and Disposition December 2024, 52 (12) 1417-1428; DOI: https://doi.org/10.1124/dmd.124.001852
Brayden D. Whitlock
Department of Physiology (B.D.W., Y.M., A.R.O., M.B., D.P.S., E.M.L.), Membrane Protein Disease Research Group (B.D.W., Y.M., M.B., D.P.S., E.M.L.), and Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology (X.C.L., E.M.L.), University of Alberta, Edmonton, Alberta, Canada; Department of Pathology and Molecular Medicine, Division of Cancer Biology and Genetics, Sinclair Cancer Research Institute, Queen’s University, Kingston, Ontario, Canada (G.C., S.P.C.C.); Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut (Z.P.L.); and Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee (Y.W., J.D.S.)
Yingze Ma
Department of Physiology (B.D.W., Y.M., A.R.O., M.B., D.P.S., E.M.L.), Membrane Protein Disease Research Group (B.D.W., Y.M., M.B., D.P.S., E.M.L.), and Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology (X.C.L., E.M.L.), University of Alberta, Edmonton, Alberta, Canada; Department of Pathology and Molecular Medicine, Division of Cancer Biology and Genetics, Sinclair Cancer Research Institute, Queen’s University, Kingston, Ontario, Canada (G.C., S.P.C.C.); Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut (Z.P.L.); and Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee (Y.W., J.D.S.)
Gwenaëlle Conseil
Department of Physiology (B.D.W., Y.M., A.R.O., M.B., D.P.S., E.M.L.), Membrane Protein Disease Research Group (B.D.W., Y.M., M.B., D.P.S., E.M.L.), and Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology (X.C.L., E.M.L.), University of Alberta, Edmonton, Alberta, Canada; Department of Pathology and Molecular Medicine, Division of Cancer Biology and Genetics, Sinclair Cancer Research Institute, Queen’s University, Kingston, Ontario, Canada (G.C., S.P.C.C.); Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut (Z.P.L.); and Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee (Y.W., J.D.S.)
Alicia R. O’Brien
Department of Physiology (B.D.W., Y.M., A.R.O., M.B., D.P.S., E.M.L.), Membrane Protein Disease Research Group (B.D.W., Y.M., M.B., D.P.S., E.M.L.), and Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology (X.C.L., E.M.L.), University of Alberta, Edmonton, Alberta, Canada; Department of Pathology and Molecular Medicine, Division of Cancer Biology and Genetics, Sinclair Cancer Research Institute, Queen’s University, Kingston, Ontario, Canada (G.C., S.P.C.C.); Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut (Z.P.L.); and Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee (Y.W., J.D.S.)
Mayukh Banerjee
Department of Physiology (B.D.W., Y.M., A.R.O., M.B., D.P.S., E.M.L.), Membrane Protein Disease Research Group (B.D.W., Y.M., M.B., D.P.S., E.M.L.), and Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology (X.C.L., E.M.L.), University of Alberta, Edmonton, Alberta, Canada; Department of Pathology and Molecular Medicine, Division of Cancer Biology and Genetics, Sinclair Cancer Research Institute, Queen’s University, Kingston, Ontario, Canada (G.C., S.P.C.C.); Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut (Z.P.L.); and Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee (Y.W., J.D.S.)
Diane P. Swanlund
Department of Physiology (B.D.W., Y.M., A.R.O., M.B., D.P.S., E.M.L.), Membrane Protein Disease Research Group (B.D.W., Y.M., M.B., D.P.S., E.M.L.), and Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology (X.C.L., E.M.L.), University of Alberta, Edmonton, Alberta, Canada; Department of Pathology and Molecular Medicine, Division of Cancer Biology and Genetics, Sinclair Cancer Research Institute, Queen’s University, Kingston, Ontario, Canada (G.C., S.P.C.C.); Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut (Z.P.L.); and Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee (Y.W., J.D.S.)
Z. Ping Lin
Department of Physiology (B.D.W., Y.M., A.R.O., M.B., D.P.S., E.M.L.), Membrane Protein Disease Research Group (B.D.W., Y.M., M.B., D.P.S., E.M.L.), and Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology (X.C.L., E.M.L.), University of Alberta, Edmonton, Alberta, Canada; Department of Pathology and Molecular Medicine, Division of Cancer Biology and Genetics, Sinclair Cancer Research Institute, Queen’s University, Kingston, Ontario, Canada (G.C., S.P.C.C.); Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut (Z.P.L.); and Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee (Y.W., J.D.S.)
Yao Wang
Department of Physiology (B.D.W., Y.M., A.R.O., M.B., D.P.S., E.M.L.), Membrane Protein Disease Research Group (B.D.W., Y.M., M.B., D.P.S., E.M.L.), and Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology (X.C.L., E.M.L.), University of Alberta, Edmonton, Alberta, Canada; Department of Pathology and Molecular Medicine, Division of Cancer Biology and Genetics, Sinclair Cancer Research Institute, Queen’s University, Kingston, Ontario, Canada (G.C., S.P.C.C.); Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut (Z.P.L.); and Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee (Y.W., J.D.S.)
X. Chris Le
Department of Physiology (B.D.W., Y.M., A.R.O., M.B., D.P.S., E.M.L.), Membrane Protein Disease Research Group (B.D.W., Y.M., M.B., D.P.S., E.M.L.), and Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology (X.C.L., E.M.L.), University of Alberta, Edmonton, Alberta, Canada; Department of Pathology and Molecular Medicine, Division of Cancer Biology and Genetics, Sinclair Cancer Research Institute, Queen’s University, Kingston, Ontario, Canada (G.C., S.P.C.C.); Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut (Z.P.L.); and Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee (Y.W., J.D.S.)
John D. Schuetz
Department of Physiology (B.D.W., Y.M., A.R.O., M.B., D.P.S., E.M.L.), Membrane Protein Disease Research Group (B.D.W., Y.M., M.B., D.P.S., E.M.L.), and Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology (X.C.L., E.M.L.), University of Alberta, Edmonton, Alberta, Canada; Department of Pathology and Molecular Medicine, Division of Cancer Biology and Genetics, Sinclair Cancer Research Institute, Queen’s University, Kingston, Ontario, Canada (G.C., S.P.C.C.); Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut (Z.P.L.); and Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee (Y.W., J.D.S.)
Susan P.C. Cole
Department of Physiology (B.D.W., Y.M., A.R.O., M.B., D.P.S., E.M.L.), Membrane Protein Disease Research Group (B.D.W., Y.M., M.B., D.P.S., E.M.L.), and Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology (X.C.L., E.M.L.), University of Alberta, Edmonton, Alberta, Canada; Department of Pathology and Molecular Medicine, Division of Cancer Biology and Genetics, Sinclair Cancer Research Institute, Queen’s University, Kingston, Ontario, Canada (G.C., S.P.C.C.); Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut (Z.P.L.); and Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee (Y.W., J.D.S.)
Elaine M. Leslie
Department of Physiology (B.D.W., Y.M., A.R.O., M.B., D.P.S., E.M.L.), Membrane Protein Disease Research Group (B.D.W., Y.M., M.B., D.P.S., E.M.L.), and Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology (X.C.L., E.M.L.), University of Alberta, Edmonton, Alberta, Canada; Department of Pathology and Molecular Medicine, Division of Cancer Biology and Genetics, Sinclair Cancer Research Institute, Queen’s University, Kingston, Ontario, Canada (G.C., S.P.C.C.); Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut (Z.P.L.); and Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee (Y.W., J.D.S.)
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Research ArticleArticle
Species Differences in Arsenic Metabolite Transport by ABCC4
Brayden D. Whitlock, Yingze Ma, Gwenaëlle Conseil, Alicia R. O’Brien, Mayukh Banerjee, Diane P. Swanlund, Z. Ping Lin, Yao Wang, X. Chris Le, John D. Schuetz, Susan P.C. Cole and Elaine M. Leslie
Drug Metabolism and Disposition December 1, 2024, 52 (12) 1417-1428; DOI: https://doi.org/10.1124/dmd.124.001852
Research ArticleArticle
Species Differences in Arsenic Metabolite Transport by ABCC4
Brayden D. Whitlock, Yingze Ma, Gwenaëlle Conseil, Alicia R. O’Brien, Mayukh Banerjee, Diane P. Swanlund, Z. Ping Lin, Yao Wang, X. Chris Le, John D. Schuetz, Susan P.C. Cole and Elaine M. Leslie
Drug Metabolism and Disposition December 1, 2024, 52 (12) 1417-1428; DOI: https://doi.org/10.1124/dmd.124.001852
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